The following test methods are accepted by the OECD to classify chemicals as inducing serious eye damage (Cat 1) according to the UN GHS (2015) and the European Union Regulation on Classification, Labelling and Packaging of chemicals (EU CLP) (2008): BCOP (OECD TG 437) (OECD, 2013a), ICE (OECD TG 438) (OECD, 2013b), Fluorescein Leakage (OECD TG The OECD Test Guideline 437 Bovine Corneal Opacity and Permeability (BCOP) test method allows determining severely irritating substances without animals, and the recently adopted OECD Test Guideline 492 Reconstructed human cornea-like epithelium test method allows identifying chemicals that neither induce eye irritation nor serious eye damage. EpiOcular™ Eye Irritation Test; EIT (OECD 492)), Reconstructed human Cornea-like Epithelium (RhCE) test method, is a bottom-up test, useful in identifying test materials that cause no irritative effects or No Category, but this assay effective use in identifying serious eye damage, and corrosion. EPIOCULAR™ EYE IRRITATION TEST (EIT) FOR IDENTIFYING CHEMICALS NOT REQUIRING CLASSIFICATION AND LABELLING 2 OECD Guidelines for the Testing of Chemicals. Reconstructed human Cornea-like Epithelium (RhCE) test method for The HET-CAM has been shown to be a qualitative method of assessing the potential irritancy of chemicals. OECD Guidelines for the Testing of Chemicals OptiSafe™ In VitroEye Irritation Test MatTek's EpiOcular® Ocular Irritation Assay Chorioallantoic Membrane Vascular Assay (CAMVA The value of the EpiOcular™ Eye Irritation Test (EIT) for the prediction of ocular non-irritants (GHS No Category) has been demonstrated, and an OECD Test Guideline (TG) was drafted in 2014. The value of the EpiOcular™ Eye Irritation Test (EIT) for the prediction of ocular non-irritants (GHS No Category) has been demonstrated, and an OECD Test Guideline (TG) was drafted in 2014. The Organisation for Economic Co-operation and Development (OECD) is an intergovernmental organisation in whic